FRCA Notes


Coughing During Extubation


  • Coughing during extubation is common, affecting up to three quarters of patients
  • A smooth, coughing-free extubation is desirable following a number of (typically head and neck) surgeries, particularly those such as:

  • There are a variety of described methods to avoid coughing (as well as bucking, straining etc.) on extubation:
  • Avoid airway manipulation entirely e.g. perform CEA under local/regional anaesthetic technique
  • Avoid endotracheal intubation entirely e.g. use a supraglottic airway device
  • Deep exchange of endotracheal tube to supraglottic device

  • Lidocaine
    • IV, intra-cuff, vocal cord topicalisation and trans-tracheal methods are described
  • Remifentanil infusion during extubation (e.g. Ce 1-2ng/ml)
  • Other short-acting opioid e.g. fentanyl
  • Dexmedetomidine
  • Is there an optimal agent?
    • The above-linked network meta-analysis appears to be the most robust resource attempting to answer this question
    • To avoid moderate-severe coughing during extubation, use of any of the above agents is better than placebo or nothing
    • The same applies to severe coughing, with the caveat that intra-cuff and trans-tracheal lidocaine are not effective
    • None of the agents was definitively superior to any other, although dexmedetomidine was most likely to be the best of the bunch